Chordoma (closed to accrual 11 / 29 / 2018) 31. Last reviewed: 19 Dec 2019. Location: 118 locations, This trial studies the side effects of pembrolizumab with or without chemotherapy in treating patients with stage IV non-small cell lung cancer that has come back (recurrent) and has spread to other places in the body (advanced). Apr 27th 2019. Hyperfractionated radiation therapy delivers smaller doses of radiation therapy over time and may kill more tumor cells and have fewer side effects. Location: 53 locations, This phase III trial compares sublobar resection (surgery to remove a portion of a lobe) and stereotactic ablative radiotherapy to see how well they work in treating patients with stage I non-small cell lung cancer. Part 2 will be conducted in two subparts, Part 2A (fixed-dose safety evaluation cohorts) and Part 2B (expansion cohorts). A database of privately and publicly funded clinical studies conducted around the world. Coronavirus and cancer. Information and help. If your lung cancer has spread to your liver, you may not have any symptoms at all. This method can kill tumor cells with fewer doses over a shorter period and cause less damage to normal tissue. Drugs used in maintenance chemotherapy, such as docetaxel, pemetrexed disodium, and gemcitabine work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether proton chemoradiotherapy is more effective than photon chemoradiotherapy in treating non-small cell lung cancer. Leaders in advancing lung cancer treatment The UCI Chao Family Comprehensive Cancer Center is a leader in first-in-human trials of targeted therapies Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. It is not yet known whether a combination of biomarker / ALK inhibitors or chemotherapy may work better in treating patients with ALK positive non-squamous non-small cell lung cancer. Location: 31 locations, This is a Phase 2, open-label, multi-center study to evaluate the efficacy and the safety / tolerability of poziotinib in seven patient cohorts for up to 603 previously treated and treatment-naïve NSCLC patients. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Pancreatic adenocarcinoma is not eligible 9. For patients or family members seeking information about lung cancer please visit our website or contact our free Lung Cancer Support Nurse Telehealth Service on the freecall number 1800 654 301. The Australian Cancer Trials website has been developed by Cancer Australia, in partnership with the Australian New Zealand Clinical Trials Registry, the University of Sydney and Cancer Voices. Location: 17 locations, The purpose of this study is to evaluate the dose, safety, immunogenicity and early clinical activity of GRT-C903 and GRT-R904, a neoantigen-based therapeutic cancer vaccine, in combination with immune checkpoint blockade, in patients with advanced or metastatic non-small cell lung cancer, microsatellite stable colorectal cancer, pancreatic cancer, and shared neoantigen-positive tumors. Location: 911 locations, This phase III trial studies how well an antibody (durvalumab) with chemotherapy and radiation therapy (chemoradiation) works in treating patients with stage III non-small cell lung cancer that cannot be removed by surgery (unresectable). We offer participation in clinical trials, including experimental targeted lung cancer therapy for ALK-positive non-small cell lung cancer. Receiving additional care from the clinical trial staff. This phase III ALCHEMIST trial studies how well crizotinib works in treating patients with stage IB-IIIA non-small cell lung cancer that has been removed by surgery and has a mutation in a protein called anaplastic lymphoma kinase (ALK). Location: 52 locations, This trial studies the side effects of radiation therapy followed by atezolizumab in treating patients with stage II or III non-small cell lung cancer. Giving atezolizumab and radiation therapy may work better than radiation therapy alone in treating patients with early non-small cell lung cancer. Peripheral nerve sheath tumors and NF1-related tumors (closed to accrual 09 / 19 / 2018) 29. Research is looking into all aspects of lung cancer and aims to improve tests, treatment, and ways of coping with symptoms and side effects. 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